Searchable abstracts of presentations at key conferences in endocrinology

ea0073yi5 | Young Investigator Awards | ECE2021

Atlas of G protein-coupled receptors in radioiodine-refractory thyroid cancer: Novel therapeutic targets for drug repositioning?

Suteau Valentine , Valérie Seegers , Munier Mathilde , Boubaker Rym Ben , Illouz Frederic , Ghamrawi Sarah , Briet Marie , Rodien Patrice , Briet Claire

IntroductionProgressive and radioiodine-refractory thyroid cancer has poor outcomes and limited therapeutic options (i.e tyrosine kinase inhibitors) due to the transient efficacy of treatment and toxic effects. Therefore, combinatorial treatment with new therapeutic approaches are needed. Many studies link G Protein-Coupled Receptors (GPCRs) to cancer. The aim of this study is to present the first specific atlas of GPCRs expression in progressive and ref...